Cuyahoga County is a county located in the state of Ohio, United States. It is the most populous county in Ohio; according to the 2010 census, it has a population of 1,280,122 which is a decrease of 8.2% from 1,393,978 in 2000. Its county seat is Cleveland. Cuyahoga County is part of Greater Cleveland, a metropolitan area, and Northeast Ohio, a thirteen-county region, joined together in economic development initiatives. The county is named after the Iroquoian word Cuyahoga, which means ‘crooked river’. The name is also assigned to the Cuyahoga River, which bisects the county. Former U.S. President James A. Garfield was born in what was Cuyahoga County’s Orange Township.